Do you know how many times Jensen has answered those questions? He couldn't hear the question the girl was asking anyway. It's not like he's always asking for Dean to get paired off with female characters. When he says "it's not that type of show" he isn't talking about the sexuality of the relationship he's talking about romantic relationships in general. Jensen has repeatedly said Dean wouldn't get into a long term relationship with a woman either.

The three times they tried to do it, he wanted nothing to do with it. He wouldn't support it doing promo. With Jo, knowing that she was planned as a romantic interest - when asked he repeatedly said Dean thought of her as a little sister. She was gone by the time the season was halfway over.

With Bella, whenever Jensen was asked, he would start talking about something else. One time it was funny because they asked him a question that was clearly supposed to get him to talk about the new recurring female characters and Bella in particular, play up the potential romantic angle, instead he started complimenting a character who had had a minor little supporting role in one of the episodes and said how nice it was to work with her. Bella was gone at the end of the season.

Then with Lisa, with whom they wrote Dean having a year long(between seasons) relationship with, he outright criticized the show for ever putting Dean into that relationship. Not after the fact, but while they were still filming it. The only time he ever did that. He said it was out of character(it was) and just wasn't down with "domesticated Dean" at all. She was gone by the end of the season. He didn't even pretend to like that storyline.

So if he wasn't in it for the those heterosexual romantic relationships, because he felt it wasn't the way Dean worked, why in the world would he be anymore welcoming to the idea of Dean in a romantic relationship with Castiel?

It's just that with the female characters, the characters themselves were not very popular, so they weren't asking him many questions about it. But with Castiel, those fans are like a dog with a frigging bone. No matter how many times they get told "no they are best friends, nothing else is going to happen between them", they insist on trying to find anyway they can to bring it up and to get him agree with them or so they can use it to say "Waaaah he's a phobe!!!!".

Oh so progressive Misha queerbaits the fans, repeatedly and then Jensen gets painted as the bad guy for telling them the truth. Most of the ones whining about it aren't even bisexual or queer. They are just middle aged women living out some slash fantasy and claiming it makes them progressive and woke. The girl who asked that question, which the audience made a ruckus over, wasn't even mad about it.

Funny they blame Jensen for allowing Robertsons and his wife to have a food truck at the brewery yet if Jensen is so god damned awful why does wonderful oh so progressive Misha like Jensen and Danneel so much? Why is Misha not awful for being friends with them? Double-standard much. Misha is clearly much more friendly with them than with Jared Padalecki and his wife(who introduced Jensen and Danneel to the Robertsons in the first place).